International Review of Ophthalmology ›› 2021, Vol. 45 ›› Issue (6): 546-550.doi: 10.3760/ cma.j.issn.1673-5803.2021.06.015

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Research progress on the pathogenesis of pterygium

Zhang Xin, Jiang Yaping, Chen Yihui   

  1. Department of Ophthalmology, Yangpu Hospital, School of Medicine, Tongji University,  Shanghai 200090, China

  • Received:2021-04-13 Online:2021-12-22 Published:2021-12-22
  • Contact: Chen Yihui, Email: cyh80h@163.com
  • Supported by:
     Project of Key Discipline of Yangpu District of Shanghai (YP19ZA01)

Abstract: Pterygium is a common ocular surface disease. Long-term chronic ultraviolet radiation is the most important factor in the development of pterygium. The oxidative stress, chronic inflammation, hyperplasia and apoptosis, extracellular matrix remodeling and heredity caused by ultraviolet rays are important mechanisms of the pathogenesis of pterygium. In addition to the  P53 gene mutations, epigenetics including m6A methylation, DNA methylation, and various non-coding RNA regulation are also found to play an important role in the pathogenesis of pterygium. (Int Rev Ophthalmol, 2021, 45: 546-550)


Key words: pterygium, non-coding RNA